A new endometrial thermal balloon ablation treatment for menorrhagia is modeled mathematically to predict its efficacy and safety. A device preheats a fluid to 173°C within a reservoir external to the uterus, and then pulses this fluid without further heating between the reservoir and the balloon for 2.1 min of treatment time. The model predicted this treatment to result in consistent immediate tissue death (coagulation) depths of 3.4±0.1 mm for uterine cavities of 7 to 26 mL, and that eventual necrosis (tissue death that would occur 1–5 days post burn) may occur to depths of 6.5±0.2 mm. Whereas, burn depths varied with uterine cavity volume when a low temperature treatment (constant 75°C for 15 min) was modeled (2.3–2.9 mm and 6.8–8.2 mm, for immediate tissue death and eventual necrosis respectively). Similarly, the high temperature, pulsed treatment was less sensitive to blood perfusion rate than the low temperature treatment. Predicted eventual necrosis depth was 1.5 mm less for the high temperature, pulsed treatment than that predicted for a low temperature treatment (constant 87°C for 7 min) for the same immediate tissue death depth (3.5 mm), indicating that the new high temperature treatment may result in less damage to non targeted tissues.
Endometrial Thermal Balloon Ablation Using a High Temperature, Pulsed System: A Mathematical Model
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division September 16, 2002; revision received June 23, 2003. Associate Editor: M. Toner.
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Reinders , D. M., Baldwin, S. A., and Bert , J. L. (January 9, 2004). "Endometrial Thermal Balloon Ablation Using a High Temperature, Pulsed System: A Mathematical Model ." ASME. J Biomech Eng. December 2003; 125(6): 841–851. https://doi.org/10.1115/1.1634279
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