The controversy over the use of nonpulsatile versus pulsatile pumps for maintenance of normal organ function during ex vivo perfusion has continued for many years, but resolution has been limited by lack of a congruent mathematical definition of pulsatility. We hypothesized that the waveform frequency and amplitude, as well as the underlying mean distending pressure are all key parameters controlling vascular function. Using discrete Fourier Analysis, our data demonstrate the complexity of the pulmonary arterial pressure waveform in vivo and the failure of commonly available perfusion pumps to mimic in vivo dynamics. In addition, our data show that the key harmonic signatures are intrinsic to the perfusion pumps, are similar for flow and pressure waveforms, and are unchanged by characteristics of the downstream perfusion circuit or perfusate viscosity.
Harmonic Analysis of Perfusion Pumps
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received June 14, 2002; final revision, July 7, 2003. Associate Editor: J.D. Humphrey.
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
- Search Site
Dougherty, F. C., Donovan, , F. M., and Townsley, M. I. (January 9, 2004). "Harmonic Analysis of Perfusion Pumps ." ASME. J Biomech Eng. December 2003; 125(6): 814–822. https://doi.org/10.1115/1.1632524
Download citation file:
- Ris (Zotero)
- Reference Manager