The goal of this study was to quantify the effect of hemodynamic pressure, flow and waveform perturbations on the deposition of protein-sized particles in porcine carotid arteries ex vivo. An ex vivo perfusion system was used to control the pressure and flow environment for excised arterial tissue. Confocal laser microscopy images revealed that 200 nm particles were deposited intimally and that more spheres were evident along vessels perfused under oscillatory waveform conditions than all others. Under all pressure, flow and waveform conditions, particles were excluded from the media and adventitia of the vessel wall. The steady flow data support the use of Darcy’s Law with pressure-dependent hydraulic permeability to model arterial tissue.
Particle Deposition in Arteries Ex Vivo: Effects of Pressure, Flow, and Waveform
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Heat Transfer Division July 23, 2001; revision received February 3, 2003. Associate Editor: A. P. Yoganathan.
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Chesler, N. C., and Enyinna, O. C. (June 10, 2003). "Particle Deposition in Arteries Ex Vivo: Effects of Pressure, Flow, and Waveform ." ASME. J Biomech Eng. June 2003; 125(3): 389–394. https://doi.org/10.1115/1.1572905
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