The mass transfer behavior in the recirculation region downstream of an axisymmetric sudden expansion was examined. The Reynolds number, 500, and Schmidt number, 3200, were selected to model the mass transfer of molecules, such as ADP, in the arterial system. In a first step the transient mass transport applying zero diffusive flux at the wall was analyzed using experiments and two computational codes. The two codes were FLUENT, a commercially available finite volume method, and FTSP, a finite element code developed at Graz University of Technology. The comparison of the transient wall concentration values determined by the three methods was excellent and provides a measure of confidence for computational mass transfer calculations in convection dominated, separated flows. In a second step the effect of the flow separation on the stationary mass transport applying a permeability boundary condition at the water-permeable wall was analyzed using the finite element code FTSP. The results show an increase of luminal ADP surface concentration in the upstream and in the downstream tube of the sudden expansion geometry in the range of six and twelve percent of the bulk flow concentration. The effect of flow separation in the downstream tube on the wall concentration is a decrease of about ten percent of the difference between wall concentration and bulk concentration occurring at nearly fully developed flow at the downstream region at a distance of 66 downstream tube diameters from the expansion. The decrease of ADP flux into the wall is in the range of three percent of the flux at the downstream region.

1.
Ku
,
D. N.
,
Giddens
,
D. P.
,
Zarins
,
C. K.
, and
Glagov
,
S.
,
1985
, “
Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation
,”
Atherosclerosis
,
5
, pp.
293
302
.
2.
Caro
,
C. G.
,
Fitz-Gerald
,
J. M.
, and
Schroter
,
R.C.
,
1971
, “
Atheroma and Arterial Wall Shear–Observation, Correlation and Proposal of a Shear Dependent Mass Transfer Mechanism for Atherogenesis
,”
Proc. R. Soc. Lond. Biol.
,
177
, pp.
109
159
.
3.
Ma
,
P.
,
Li
,
X.
, and
Ku
,
D. N.
,
1994
, “
Heat and Mass Transfer in a Separated Flow Region for High Prandtl and Schmidt Numbers Under Pulsatile Conditions
,”
Int. J. Heat Mass Transf.
,
37
, pp.
2723
2736
.
4.
McIntire, L. V., and Tran-Son-Tay, R., 1989, “Concentration of Materials Released from Mural Platelet Aggregates: Flow Effects,” in Biomedical Engineering (Edited by W.-J. Yang and C.-J. Lee), Hemisphere Publ. Corp., NY, pp. 229-245.
5.
Renkin, E. M., and Crone, C., 1996, “Microcirculation and Capillary Exchange,” in Comprehensive Human Physiology (edited by R. Gregor and U. Windhorst), Springer Verlag, Berlin, 1965–1979.
6.
Wada, S., and Karino, T., 2000, “Computational Study on LDL Transfer from Flowing Blood to Arterial Walls,” in Clinical Application of Computational Mechanics to the Cardiovascular System (edited by T. Yamaguchi), Springer Verlag, Tokyo, pp. 157–173.
7.
Karner
,
G.
,
Perktold
,
K.
, and
Zehentner
,
H. P.
,
2001
, “
Computational Modeling of Macromolecule Transport in the Arterial Wall
,”
Computer Methods in Biomechanics and Biomedical Engineering
,
4
, pp.
491
504
.
8.
Perktold
,
K.
,
1987
, “
On Numerical Simulation of Three-Dimensional Physiological Flow Problems
,”
Ber. Math. Stat. Sektion, Forschungsges. Joanneum Graz. Nr.
,
280
,
5
5
.
9.
Hilbert, D., 1987, “Ein Finite Element-Aufspaltungsverfahren zurnumerischem Lo¨sung der Navier-Stokes-Gleichungen and seine Anwendung auf die Stro¨mung in Rohren mit Elastischem Wa¨nden,” Diss., TU-Graz.
10.
Perktold
,
K.
,
Resch
,
M.
, and
Florian
,
H.
,
1991
, “
Pulsatile Non-Newtonian Flow Characteristics in a Three-dimensional Human Carotid Bifurcation Model
,”
ASME J. Biomech. Eng.
113
, pp.
464
475
.
11.
Perktold, K., and Rappitsch, G., 1994, “Mathematical Modeling of Local Arterial Flow and Vessel Mechanics,” in Computational Methods for Fluid-Structure Interaction, (edited by J. M. Crolet and R. Ohayon), Pitman Research Notes in Methematics, Longman Scientific & Technical, NY, 306, pp. 230–245.
12.
Perktold
,
K.
, and
Rappitsch
,
G.
,
1995
, “
Computer Simulation of Local Flood Flow and Vessel Mechanics in a Compliant Carotid Artery Bifurcation Model
,”
J. Biomech.
,
28
, pp.
845
856
.
13.
Chorin
,
A. J.
,
1968
, “
Numerical Solution of the Navier-Stokes Equation
,”
Math. Comput.
,
22
, pp.
745
762
.
14.
Girault, H. G., and Raviart, P. A., 1986, “Finite Element Methods for Navier-Stokes Equations,” Springer Verlag, Berlin.
15.
Rappitsch
,
G.
, and
Perktold
,
K.
,
1996
, “
Computer Simulation of Convective Diffusion Processes in Large Arteries
,”
J. Biomech.
,
29
, pp.
207
215
.
16.
Rappitsch
,
G.
, and
Perktold
,
K.
,
1996
, “
Pulsatile Albumin Transport in Large Arteries: A Numerical Simulation Study
,”
ASME J. Biomech. Eng.
,
118
, pp.
511
519
.
17.
Brooks
,
A. N.
, and
Hughes
,
T. J. R.
,
1982
, “
Streamline Upwind/Petrov-Galerkin Formulations for Convection Dominated Flows with Particular Emphasis on the Incompressible Navier-Stokes Equations
,”
Comput. Methods Appl. Mech. Eng.
,
32
, pp.
199
259
.
18.
Rappitsch, G., 1996, “Stable Finite Element Methods for Convection-Dominated Diffusion Processes and Application to Cardiovascular Transport Problems,” Ph.D. Thesis (in German), Technical University Graz.
19.
Wada
,
S.
, and
Karino
,
T.
,
1999
, “
Theoretical Study on Flow-Dependent Concentration Polarization of Low Density Lipoproteins at the Luminal Surface of a Straight Artery
,”
Biorheology
,
36
, pp.
207
223
.
20.
Fletcher
,
D. F.
,
Maskell
,
S. J.
, and
Patrick
,
M. A.
,
1985
, “
Heat and Mass Transfer Computations for Laminar Flow in an Axisymmetric Sudden Expansion
,”
Comput. Fluids
,
13
, pp.
207
221
.
21.
Schoephoerster
,
R. T.
,
Oynes
,
F.
,
Nunez
,
G.
,
Kapadvanjwala
,
M.
, and
Dewanjee
,
M. K.
,
1993
, “
Effects of Local Geometry and Fluid Dynamics on Regional Platelet Deposition on Artificial Surfaces
,”
Arterioscler. Thromb.
,
13
, (
12
) pp.
1806
1813
.
22.
Ross
,
R.
, et al.
,
1977
, “
Response to Injury and Atherogenesis
,”
Am. J. Pathol.
,
6
, p.
75
75
.
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