Previous echocardiographic techniques for quantifying valvular regurgitation (PISA) are limited by factors including uncertainties in orifice location and hemispheric convergence assumption. Using computational fluid dynamics simulations, we developed a new model for the estimation of orifice diameter and regurgitant volume without the aforementioned assumptions of the PISA technique. Using experimental data obtained from the in vitro flow model we successfully validated our new model. The model output (y) and reference (x) values were in close agreement (y=0.95x+0.38,r=0.96,error=1.68±7.54% for the orifice diameter and y=1.18x4.72,r=0.93,error=6.48±16.81% for the regurgitant volume).

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