We have developed an in vitro method for creating pulsatile flows to mimic coronary type flow patterns on a beat-to-beat basis. The flow is created by accelerating fluid loops about an axis, inducing relative wall motion. Using this technique, a variety of oscillating flow patterns can be generated and modulated. Such flow generation offers the potential to monitor sensitive, flow-dependent, biological parameters like thrombosis while minimizing background disturbances from pump action and circuit effects. We examined this potential by measuring the loop occlusion time for loops stented with stainless steel 7-9 NIR® stents and stentless control loops.
Low Background, Pulsatile, In Vitro Flow Circuit for Modeling Coronary Implant Thrombosis
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received April 2001; revised manuscript received June 2002. Associate Editor: A. P. Yoganathan.
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Kolandaivelu, K., and Edelman, E. R. (December 27, 2002). "Low Background, Pulsatile, In Vitro Flow Circuit for Modeling Coronary Implant Thrombosis ." ASME. J Biomech Eng. December 2002; 124(6): 662–668. https://doi.org/10.1115/1.1517062
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