Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.
Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry: Insight from In Vitro Validation of the Premise of Force Equilibrium
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received Mar. 1999; revised manuscript received Apr. 2002. Associate Editor: V. T. Turitto.
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Nielsen, S. L., Nygaard, H., Mandrup, L., Fontaine, A. A., Hasenkam, J. M., He , S., and Yoganathan, A. P. (September 30, 2002). "Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry: Insight from In Vitro Validation of the Premise of Force Equilibrium." ASME. J Biomech Eng. October 2002; 124(5): 596–608. https://doi.org/10.1115/1.1500741
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