Two-dimensional physical models of the human head were used to investigate how the lateral ventricles and irregular skull base influence kinematics in the medial brain during sagittal angular head dynamics. Silicone gel simulated the brain and was separated from the surrounding skull vessel by paraffin that provided a slip interface between the gel and vessel. A humanlike skull base model (HSB) included a surrogate skull base mimicking the irregular geometry of the human. An HSBV model added an elliptical inclusion filled with liquid paraffin simulating the lateral ventricles to the HSB model. A simplified skull base model (SSBV) included ventricle substitute but approximated the anterior and middle cranial fossae by a flat and slightly angled surface. The models were exposed to 7600 rad/s2 peak angular acceleration with 6 ms pulse duration and 5 deg forced rotation. After 90 deg free rotation, the models were decelerated during 30 ms. Rigid body displacement, shear strain and principal strains were determined from high-speed video recorded trajectories of grid markers in the surrogate brains. Peak values of inferior brain surface displacement and strains were up to 10.9X (times) and 3.3X higher in SSBV than in HSBV. Peak strain was up to 2.7X higher in HSB than in HSBV. The results indicate that the irregular skull base protects nerves and vessels passing through the cranial floor by reducing brain displacement and that the intraventricular cerebrospinal fluid relieves strain in regions inferior and superior to the ventricles. The ventricles and irregular skull base are necessary in modeling head impact and understanding brain injury mechanisms.

1.
Holbourn
,
A. H. S.
,
1943
, “
Mechanics of Head Injuries
,”
Lancet
, October
9
, pp.
438
441
.
2.
Aldman, B., Ljung, C., and Thorngren, L., 1982, “Intracranial Deformation Patterns Due to Impulsive Loading—A Model Study,” Proceedings, 9th International Technical Conference on Experimental Safety Vehicles, pp. 269–274.
3.
Ross
,
D. T.
,
Meaney
,
D. F.
,
Sabol
,
M. K.
,
Smith
,
D. H.
, and
Gennarelli
,
T. A.
,
1994
, “
Distribution of Forebrain Axonal Injury Following Inertial Closed Head Injury in Miniature Swine
,”
Exp. Neurol.
,
126
, pp.
291
299
.
4.
Miller, R. T., Margulies, S. S., Leoni, M., Nonaka, M., Chen, X., Smith, D. H., and Meaney, D. F., 1998, “Finite Element Modeling Approaches for Predicting Injury in an Experimental Model of Severe Diffuse Axonal Injury,” Proceedings, 42nd Stapp Car Crash Conference, pp. 155–167.
5.
Zhou, C., Khalil, T. B., and King, A. I., 1994, “Shear Stress Distribution in the Porcine Brain due to Rotational Impact,” Proceedings, 38th Stapp Car Crash Conference, pp. 133–143.
6.
Zhou, C., Khalil, T. B., and King, A. I., 1995, “A New Model Comparing Impact Responses of the Homogeneous and Inhomogeneous Human Brain,” Proceedings, 39th Stapp Car Crash Conference, pp. 121–137.
7.
Nishimoto
,
T.
, and
Murakami
,
S.
,
1998
, “
Relation Between Diffuse Axonal Injury and Internal Head Structures on Blunt Impact
,”
ASME J. Biomech. Eng.
,
120
, pp.
140
147
.
8.
Viano
,
D. C.
,
Aldman
,
B.
,
Pape
,
K.
,
van Hoof
,
J.
, and
von Holst
,
H.
,
1997
, “
Brain Kinematics in Physical Model Tests with Translational and Rotational Acceleration
,”
International Journal of Crashworthiness
,
2
, pp.
191
206
.
9.
Courville
,
C. B.
,
1942
, “
Coup-Countrecoup Mechanism of Craniocerebral Injuries. Some Observations
,”
Arch. Surg.
4
, pp.
19
43
.
10.
Gurdjian
,
E. S.
,
Webster
,
J. E.
, and
Lissner
,
H. R.
,
1955
, “
Observations on the Mechanism of Brain Concussion, Contusion, and Laceration
,”
Surg. Gynecol. and Obstet.
,
101
, pp.
680
690
.
11.
Gurdjian
,
E. S.
, and
Gurdjian
,
E. S.
,
1976
, “
Cerebral Contusions: Re-Evaluation of the Mechanism of Their Development
,”
J. Trauma
,
16
, pp.
35
51
.
12.
Viano, D. C., 1985, “Perspectives on Head Injury Research,” Proceedings, 1985 International IRCOBI/AAAM Conference on the Biomechanics of Impacts, pp. 159–176.
13.
Chu
,
C. S.
,
Lin
,
M. S.
,
Huang
,
H. M.
, and
Lee
,
M. C.
,
1994
, “
Finite Element Analysis of Cerebral Contusion
,”
J. Biomech.
,
27
, pp.
187
194
.
14.
Lawson, A. R., and Sadeghi, M. M., 1998, “Finite Element Modelling of Blunt or Non-Contact Head Injuries,” Proceedings, 16th International Technical Conference on the Enhanced Safety of Vehicles, pp. 2080–2092.
15.
Willinger
,
R.
,
Kang
,
H. S.
, and
Diaw
,
B.
,
1999
, “
Three-Dimensional Human Head Finite-Element Model Validation Against Two Experimental Impacts
,”
Ann. Biomed. Eng.
,
27
, pp.
403
410
.
16.
Ivarsson
,
J.
,
Viano
,
D. C.
,
Lo¨vsund
,
P.
, and
Aldman
,
B.
,
2000
, “
Strain Relief From the Cerebral Ventricles During Head Impact: Experimental Studies on Natural Protection of the Brain
,”
J. Biomech.
,
33
, pp.
181
189
.
17.
Ivarsson
,
J.
,
Viano
,
D. C.
, and
Lo¨vsund
,
P.
,
2001
, “
Influence of the Anterior and Middle Cranial Fossae on Brain Kinematics During Sagittal Plane Head Rotation
,”
Journal of Crash Prevention and Injury Control
,
4
, pp.
271
287
.
18.
Aldman, B., Thorngren, L., and Ljung, C., 1981, “Patterns of Deformation in Brain Models Under Rotational Motion,” Poceedings, Head and Neck Injury Criteria—A Consensus Workshop, Department of Transportation Publication DOT HS 806 434, pp. 163–168.
19.
Bradshaw
,
D. R. S.
,
Ivarsson
,
J.
,
Morfey
,
C. L.
, and
Viano
,
D. C.
,
2001
, “
Simulation of Acute Subdural Hematoma and Diffuse Axonal Injury in Coronal Head Impact
,”
J. Biomech.
,
34
, pp.
85
94
.
20.
Margulies, S. S., 1987, “Biomechanics of Traumatic Coma in the Primate,” Ph.D. thesis, University of Pennsylvania, Philadelphia, PA, UMI Dissertation Services, Ann Arbor, MI.
21.
Margulies, S. S., Thibault, L. E., and Gennarelli, T. A., 1985, “A Study of Scaling and Head Injury Criteria using Physical Model Experiments,” Proceedings, 1985 International IRCOBI/AAAM Conference on the Biomechanics of Impacts, pp. 223–234.
22.
Margulies
,
S. S.
,
Thibault
,
L. E.
, and
Gennarelli
,
T. A.
,
1990
, “
Physical Model Simulations of Brain Injury in the Primate
,”
J. Biomech.
,
23
, pp.
823
836
.
23.
Meaney, D. F., and Thibault, L. E., 1990, “Physical Model Studies of Cortical Brain Deformation in Response to High Strain Rate Inertial Loading,” Proceedings, 1990 International IRCOBI Conference on the Biomechanics of Impacts, pp. 215–224.
24.
Meaney, D. F., 1991, “Biomechanics of Acute Subdural Hematoma in the Subhuman Primate and Man,” Ph.D. thesis, University of Pennsylvania, Philadelphia, PA, UMI Dissertation Services, Ann Arbor, MI.
25.
Meaney, D. F., Thibault, K. L., Gennarelli, T. A., and Thibault, L. E., 1993, “Experimental Investigation of the Relationship Between Head Kinematics and Intracranial Tissue Deformation,” Proceedings, ASME 1993 Bioengineering Conference, BED-Vol. 24, pp. 8–11.
26.
Meaney, D. F., Smith, D. S., Shreiber, D. I., Rahdert, D. A., Bogen, D. K., Ross, D. T., McIntosh, T. K., and Gennarelli, T. A., 1994, “Prediction of Experimental Diffuse Axonal Injury Severity Using Macroscopic Head Motion Parameters,” Proceedings, 38th Annual Association for the Advancement of Automotive Medicine Conference, pp. 345–357.
27.
Meaney
,
D. F.
,
Smith
,
D. H.
,
Shreiber
,
D. I.
,
Bain
,
A. C.
,
Miller
,
R. T.
,
Ross
,
D. T.
, and
Gennarelli
,
T. A.
,
1995
, “
Biomechanical Analysis of Experimental Diffuse Axonal Injury
,”
J. Neurotrauma
,
12
, pp.
689
694
.
28.
Shreiber, D. I., Gennarelli, T. A., and Meaney, D. F., 1995, “The Incidence of Cerebral Contusions in the Human: A Physical Modeling Study,” Proceedings, 1995 International IRCOBI Conference on the Biomechanics of Impact, pp. 233–244.
29.
Thibault, L. E., Bianchi, A., Galbraith, J., and Gennarelli, T. A., 1982, “Analysis of the Strains Induced in Physical Models of the Baboon Brain Undergoing Inertial Loading,” Proceedings, 35th Annual Conference on Engineering in Medicine and Biology, pp. 8.
30.
Thibault, L. E., Bianchi, A., Galbraith, J., and Gennarelli, T. A., 1982, “Physical Model Experiments of the Brain Undergoing Dynamic Loading,” ASME Advances in Bioengineering, pp. 39–42.
31.
Thibault, L. E., Margulies, S. S., and Gennarelli, T. A., 1987, “The Temporal and Spatial Deformation Response of a Brain Model in Inertial Loading,” Proceedings, 31st Stapp Car Crash Conference, pp. 267–272.
32.
Brands, D. W. A., Bovendeerd, P. H. M., Peters, G. W. M., Wismans, J. H. S. M., Paas, M. H. J. W., and van Bree, J. L. M. J., 1999, “Comparison of the Dynamic Behaviour of Brain Tissue and Two Model Materials,” Proceedings, 43rd Stapp Car Crash Conference, pp. 313–320.
33.
Brands
,
D. W. A.
,
Bovendeerd
,
P. H. M.
,
Peters
,
G. W. M.
, and
Wismans
,
J. H. S. M.
,
2000
, “
The Large Shear Strain Dynamic Behaviour of In-Vitro Porcine Brain Tissue and Silicone Gel Model Material
,”
Stapp Car Crash Journal
,
44
, pp.
249
260
.
34.
Kohn
,
M. I.
,
Tanna
,
N. K.
,
Herman
,
G. T.
,
Resnick
,
S. M.
,
Mozley
,
P. D.
,
Gur
,
R. E.
,
Alavi
,
A.
,
Zimmerman
,
R. A.
, and
Gur
,
R. C.
,
1991
, “
Analysis of Brain and Cerebrospinal Fluid Volumes with MR Imaging, Part I. Methods, Reliability and Validation
,”
Radiology
,
178
, pp.
115
122
.
35.
Gosch
,
H. H.
,
Gooding
,
E.
, and
Schneider
,
R. C.
,
1969
, “
Distortion and Displacement of the Brain in Experimental Head Injuries
,”
Surg. Forum
,
20
, pp.
425
426
.
36.
Gosch
,
H. H.
,
Gooding
,
E.
, and
Schneider
,
R. C.
,
1970
, “
The Lexan Calvarium for the Study of Cerebral Responses to Acute Trauma
,”
J. Trauma
,
10
, pp.
370
376
.
37.
Ommaya
,
A. K.
,
Boretos
,
J. W.
, and
Beile
,
E. E.
,
1969
, “
The Lexan Calvarium: An Improved Method for Direct Observation of the Brain
,”
J. Neurosurg.
,
30
, pp.
25
29
.
38.
Pudenz
,
R. H.
, and
Shelden
,
C. H.
,
1946
, “
The Lucite Calvarium-A Method for Direct Observation of the Brain. II. Cranial Trauma and Brain Movement
,”
J. Neurosurg.
,
3
, pp.
487
505
.
39.
Lee, M. C., Melvin, J. W., and Ueno, K., 1987, “Finite Element Analysis of Traumatic Subdural Hematoma,” Proceedings, 31st Stapp Car Crash Conference, pp. 67–77.
40.
Lighthall, J. W., Melvin, J. W., and Ueno, K., 1989, “Toward a Biomechanical Criterion for Functional Brain Injury,” Proceedings, 12th International Technical Conference on Experimental Safety Vehicles, pp. 627–633.
41.
Ueno
,
K.
, and
Melvin
,
J. W.
,
1995
, “
Finite Element Model Study of Head Impact Based on Hybrid III Head Acceleration: The Effects of Rotational and Translational Acceleration
,”
J. Biomech. Eng.
,
117
, pp.
319
328
.
42.
Ward, C., and Chan, M., 1980, “Rotation Generated Shear Strains in the Brain,” Proceedings, 8th Annual International Workshop on Human Subjects for Biomechanical Research, pp. 11–29.
43.
DiMasi, F. P., Eppinger, R. H., and Bandak, F. A., 1995, “Computational Analysis of Head Impact Response Under Car Crash Loadings,” Proceedings, 39th Stapp Car Crash Conference, pp. 425–438.
44.
Viano, D. C., 1988, “Biomechanics of Head Injury—Toward a Theory Linking Head Dynamic Motion, Brain Tissue Deformation and Neural Trauma,” Proceedings, 32nd Stapp Car Crash Conference, pp. 1–20.
45.
Hodgson, V. R., and Thomas, L. M., 1979, “Acceleration Induced Shear Strains in a Monkey Brain Hemisection,” Proceedings, 23rd Stapp Car Crash Conference, pp. 589–611.
46.
Donnelly, B. R., 1998, “Brain Tissue Material Properties: A Comparison of Results,” Proceedings, 26th International Workshop on Experimental and Computational Biomechanics Research, pp. 47–57.
47.
Gennarelli
,
T. A.
,
Thibault
,
L. E.
,
Adams
,
J. H.
,
Graham
,
D. I.
,
Thompson
,
C. J.
, and
Marcincin
,
R. P.
,
1982
, “
Diffuse Axonal Injury and Traumatic Coma in the Primate
,”
Ann. Neurol.
,
12
, pp.
564
574
.
48.
Gennarelli, T. A., Thibault, L. E., Tomei, G., Wiser, R., Graham, D., and Adams, J., 1987, “Directional Dependence of Axonal Brain Injury due to Centroidal and Non-Centroidal Acceleration,” Proceedings, 31st Stapp Car Crash Conference, pp. 49–53.
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