A method is described for construction of an in vitro flow model based on in vivo measurements of the lumen geometry of the human carotid bifurcation. A large-scale physical model of the vessel lumen was constructed using fused deposition modeling (a rapid prototyping technique) based on magnetic resonance (MR) images of the carotid bifurcation acquired in a healthy volunteer. The lumen negative was then used to construct a flow model for experimental studies that examined the hemodynamic environment of subject-specific geometry and flow conditions. The physical model also supplements physician insight into the three-dimensional geometry of the arterial segment, complementing the two-dimensional images obtained by MR. Study of the specific geometry and flow conditions in patients with vascular disease may contribute to our understanding of the relationship between their hemodynamic environment and conditions that lead to the development and progression of arterial disease.
Construction of a Physical Model of the Human Carotid Artery Based Upon In Vivo Magnetic Resonance Images
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division May 11, 1999; revised manuscript received February 7, 2001. Associate Editor: C. R. Ethier.
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Yedavalli , R. V., Loth , F., Yardimci, A., Pritchard , W. F., Oshinski , J. N., Sadler , L., Charbel , F., and Alperin , N. (May 11, 1999). "Construction of a Physical Model of the Human Carotid Artery Based Upon In Vivo Magnetic Resonance Images ." ASME. J Biomech Eng. August 2001; 123(4): 372–376. https://doi.org/10.1115/1.1385845
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