The purpose of this study was to determine the hemolytic potentials of discrete bubble cavitation and attached cavitation. To generate controlled cavitation events, a venturi-geometry hydrodynamic device, called a Cavitation Susceptibility Meter (CSM), was constructed. A comparison between the hemolytic potential of discrete bubble cavitation and attached cavitation was investigated with a single-pass flow apparatus and a recirculating flow apparatus, both utilizing the CSM. An analytical model, based on spherical bubble dynamics, was developed for predicting the hemolysis caused by discrete bubble cavitation. Experimentally, discrete bubble cavitation did not correlate with a measurable increase in plasma-free hemoglobin (PFHb), as predicted by the analytical model. However, attached cavitation did result in significant PFHb generation. The rate of PFHb generation scaled inversely with the Cavitation number at a constant flow rate, suggesting that the size of the attached cavity was the dominant hemolytic factor. [S0148-0731(00)00404-0]
Hemolytic Potential of Hydrodynamic Cavitation
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division Sept. 3, 1998; revised manuscript received Jan. 5, 2000. Associate Technical Editor: D. N. Ku.
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Chambers, S. D., Bartlett, R. H., and Ceccio, S. L. (January 5, 2000). "Hemolytic Potential of Hydrodynamic Cavitation ." ASME. J Biomech Eng. August 2000; 122(4): 321–326. https://doi.org/10.1115/1.1286560
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