Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc. [S0148-0731(00)00603-8]
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June 2000
Technical Papers
The Micromechanical Environment of Intervertebral Disc Cells: Effect of Matrix Anisotropy and Cell Geometry Predicted by a Linear Model
Anthony E. Baer,
Anthony E. Baer
Department of Biomedical Engineering, Duke University, Durham, NC 27708
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Lori A. Setton
Lori A. Setton
Department of Biomedical Engineering, Duke University, Durham, NC 27708
Search for other works by this author on:
Anthony E. Baer
Department of Biomedical Engineering, Duke University, Durham, NC 27708
Lori A. Setton
Department of Biomedical Engineering, Duke University, Durham, NC 27708
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division October 31, 1999; revised manuscript received February 6, 2000. Associate Technical Editor: R. Vanderby, Jr.
J Biomech Eng. Jun 2000, 122(3): 245-251 (7 pages)
Published Online: February 6, 2000
Article history
Received:
October 31, 1999
Revised:
February 6, 2000
Citation
Baer , A. E., and Setton, L. A. (February 6, 2000). "The Micromechanical Environment of Intervertebral Disc Cells: Effect of Matrix Anisotropy and Cell Geometry Predicted by a Linear Model ." ASME. J Biomech Eng. June 2000; 122(3): 245–251. https://doi.org/10.1115/1.429655
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