A lumped parameter mathematical model to describe the propulsion of blood in the splanchnic circulation was developed by integrating the principles of mechanics and physiology. A set of governing equations by derived by specifically considering the contractility of the portal vein, hepatic vein, liver sinusoids, and of the draining lymphatics. These equations were then simulated on a computer. The present simulation results substantiate previous experimental observations that hepatic venous pressure leads to portal hypertension and increased liver interstitial fluid volume.
Issue Section:
Research Papers
Topics:
Blood,
Computers,
Drainage,
Fluids,
Gates (Closures),
Liver,
Physiology,
Pressure,
Propulsion,
Simulation results
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Copyright © 1992
by The American Society of Mechanical Engineers
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