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Keywords: pharmacokinetics
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eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1995
ISBN-10: 0-8031-1884-8
ISBN: 978-0-8031-1884-3
... We have designed and implemented a series of investigations aimed at estimating the range and extent of gastrointestinal absorption of lead from various mineralogical matrices following oral and intravenous reference substance doses and oral test substance doses. Using pharmacokinetic...
eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1993
ISBN-10: 0-8031-1875-9
ISBN: 978-0-8031-1875-1
... model. Exposure estimation is a precursor to dose determination. The latest results in our attempts to incorporate pharmacokinetic modules into human exposure models are presented. exposure simulation pharmacokinetics microenvironment Joseph K Behar, ~ Jerry N. Blancato, ~Muhilan D. Pandian...
eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1991
ISBN-10: 0-8031-1425-7
ISBN: 978-0-8031-1425-8
... Characterization of the pharmacokinetics of a chemical in fish is useful for estimation of the bioconcentration factor and half-life. Compartmental models that assume the fish to behave as one or more well-stirred compartments are the most common type of pharmacokinetic model used. A variety...
eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1991
ISBN-10: 0-8031-1425-7
ISBN: 978-0-8031-1425-8
... Assessment of the environmental hazard of a chemical generally involves characterization of its bioconcentration and pharmacokinetics in at least one species of fish under laboratory conditions. The size of the fish is usually small (<10 g) and, although the test conditions are controlled...
eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1989
ISBN-10: 0-8031-1253-X
ISBN: 978-0-8031-1253-7
.... Pharmacokinetic uptake and depuration rate constants were used to compare the potential for spot to bioaccumulate TCB, a moderately lipophilic compound, to that for chlordecone (Kepone), a highly lipophilic compound. Our results were also compared to those from a TCB bioaccumulation study with freshwater species...
eBook Chapter
Series: ASTM Selected Technical Papers
Publisher: ASTM International
Published: 1981
ISBN-10: 0-8031-0799-4
ISBN: 978-0-8031-0799-1
.... metabolism chamber aquatic toxicology fish catheterization excretion pharmacokinetics hazard assessment E. J. Schmidt^ and R. A. Kimerle^ New Design and Use of a Fish IVIetabolism CJiamber REFERENCES: Schmidt, E. J. and Kimerle, R. A., "New Design and Use of a Fish Metabolism Chamber," Aquatic...