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ASTM Selected Technical Papers
Environmental Toxicology and Risk Assessment: Biomarkers and Risk Assessment: Fifth Volume
By
DS Henshel
DS Henshel
1
Indiana University, School of Public and Environmental Affairs
,
Bloomington, IN 47405
;
Symposium Chairperson and Editor
.
Search for other works by this author on:
DA Bengtson
DA Bengtson
2
University of Rhode Island
, Department of Biological Sciences,
Kingston, RI 02881
;
Symposium Chairperson and Editor
.
Search for other works by this author on:
ISBN-10:
0-8031-2031-1
ISBN:
978-0-8031-2031-0
No. of Pages:
490
Publisher:
ASTM International
Publication date:
1996

Recent evidence indicates that avian embryonic exposure to polychlorinated dibenzodioxins (PCDDs) and related compounds is associated with the development of a gross brain asymmetry which can be quantified. Three methods can be used to quantify the asymmetry,including external measurements of the intact brain, measurements of brain cross-sections and measurements of computer tomography (CT) - generated images of brain sections. All three methods produce reliable results. The whole brain measurements do not require specialized equipment, and are the most flexible. However, the possibility for unintentional bias is greatest for this technique. The CT scan technology is non-invasive, but requires access to specialized equipment and may be expensive. The cross-sectional measurements, which are similar to the CT scan measurements, require careful processing prior to measurement.

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,
M.B.
, Ed.,
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CRC Press, Inc.
,
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.
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,
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,
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,
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,
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, and
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,
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,
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,
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. In
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American Society for Testing and Materials (ASTM)
,
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, pp. 262–280.
3.
Henshel
,
D.S.
and
Martin
,
J.W.
,
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, Brain asymmetry as a potential biomarker for developmental TCDD intoxication: a dose-response study.Seventh International Congress of Toxicology,
Seattle, WA
, July 2–6, 1995, and submitted to Biomarkers.
4.
Henshel
,
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,
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,
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,
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,
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,
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, and
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,
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,
Brain asymmetry in Double-Crested Cormorants exposedin ovo to PCBs and related compounds
. Submitted to
J. Great Lakes Research
 0380-1330.
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,
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,
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,
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,
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,
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,
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and
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,
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,
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,
Morphometric abnormalities in brains of Great Blue Heron hatchlings exposed to PCDDs
.
Environmental Health Perspectives
 0091-6765, Vol.
103
Suppl.
4
:61–66.
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Henshel
,
D.S.
,
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,
J.W.
, and
Rapp
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,
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Denver, CO
, October 30–November 3, 1994.
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Henshel
,
D.S.
,
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,
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,
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,
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,
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,
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,
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,
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,
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Huggett
,
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,
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,
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,
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,
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, Jr.
,
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,
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, Eds.,
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,
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.
9.
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,
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,
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,
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,
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,
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 Jr.
,
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,
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10.
McCarthy
,
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and
Shugart
,
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, Eds,
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, Biomarkers of Environmental Contamination,
Lewis Publishers
,
Boca Raton
.
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