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ASTM Selected Technical Papers
Medical Applications of Titanium and Its Alloys: The Material and Biological Issues
By
SA Brown, D. Eng.
SA Brown, D. Eng.
1
FDA, Center for Devices and Radiological Health
?
Rockville, MD 20852
.
Search for other works by this author on:
JE Lemons, Ph.D.
JE Lemons, Ph.D.
2
University of Alabama
at
Birmingham Birmingham, AL 35294-3295
.
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ISBN-10:
0-8031-2010-9
ISBN:
978-0-8031-2010-5
No. of Pages:
434
Publisher:
ASTM International
Publication date:
1996

Examination of retrieved orthopedic implants has identified fretting corrosion as one of the principal mechanisms of implant corrosion. Fretting may contribute to corrosion and metal ion and particle release directly, or may contribute to the initiation of crevice corrosion. A series of experiments have been conducted, as per F897. When fretting against itself, Ti 6Al 4V tends to gall and show high fretting corrosion rates. In mixed metal combinations with stainless steel or cobalt alloy, fretting corrosion of titanium is significantly reduced. Similarly, nitriding one or both faces reduces corrosion. The addition of serum proteins to a saline solution tends to increase the fretting corrosion rates. Fretting in cell culture growth media is higher in those media containing higher calcium ion concentrations or containing hydrogen peroxide.

1.
Brown
S.A.
and
Simpson
J.P.
,
Journal of Biomedical Materials Research
,
15
,
867
(
1981
).
2.
Brown
S.A.
and
Merritt
K.
,
Journal of Biomedical Materials Research
,
15
,
479
(
1981
).
3.
Brown
S.A.
and
Merritt
K.
,
Corrosion and Degradation of Implant Materials
,
Fraker
A. C.
and
Griffin
C. D.
, Editors, STP 859, p. 105,
American Society for Testing and Materials
,
Philadelphia, PA
(
1985
)
4.
Brown
S.A.
,
Hughes
P.J.
, and
Merritt
K.
,
Journal of Orthpaedic Research
.
6
, 572 (
1988
).
5.
Kawalek
J.S.
,
Brown
S.A.
,
Payer
J.H.
, and
Merritt
K.
.
Journal of Biomedical Materials Research
(in press).
6.
Maurer
A.M.
,
Brown
S.A.
,
Payer
J.H.
,
Merritt
K.
, and
Kawalec
J.S.
,
Journal of Orthpaedic Research
,
11
, 865 (
1993
).
7.
Maurer
A.M.
,
Merritt
K.
, and
Brown
S.A.
,
Journal of Biomedical Materials Research
,
28
, 241 (
1994
).
8.
Wang
J.T.
,
Willis
A.
,
Jiranek
B.
,
Merritt
K.
,
Brown
S.A.
, and
Goldring
S.R.
.
Metal particles of orthopaedic implant materials and their corrosion products stumulate release of PGE2 and Interleukin-6, products implicated in pathological bone resorption
.
Transactions of Orthopaedic Ressearch Society
,
18
: 86,
1993
.
9.
Montague
A.C.
,
Merritt
K.
,
Brown
S.A.
, and
Payer
J. H.
.
Transactions of the Society for Biomaterials
16
:263,
1994
.
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