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Book cover for Bone Graft Substitutes and Bone Regenerative Engineering
ASTM Monographs
Bone Graft Substitutes and Bone Regenerative EngineeringAvailable to Purchase
By
Cato T. Laurencin, M.D., Ph.D.
Cato T. Laurencin, M.D., Ph.D.
Editor
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PubMed
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Tao Jiang, Ph.D., MBA
Tao Jiang, Ph.D., MBA
Editor
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PubMed
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ISBN:
978-0-8031-7060-5
No. of Pages:
396
DOI:
https://doi.org/10.1520/MONO6-2ND-EB
Publisher:
ASTM International
Publication date:
2014
eBook Chapter

Chapter 15 | Regenerative Engineering: Fulfilling the Tissue Engineering Promise to Bone Regeneration Available to Purchase

By
Tao Jiang
Tao Jiang
1
Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
2
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
3
Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
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,
Jennifer I. Rulka
Jennifer I. Rulka
1
Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
4
Department of Biochemistry and Molecular Biology, University of Massachusetts
,
Amherst, MA,
US
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,
Cato T. Laurencin
Cato T. Laurencin
1
Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
2
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
5
Department of Biomedical Engineering, University of Connecticut, School of Engineering
,
Storrs, CT,
US
6
Department of Orthopedic Surgery, University of Connecticut Health Center, School of Medicine
,
Farmington, CT,
US
7
Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, School of Engineering
,
Storrs, CT,
US
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Doi:
https://doi.org/10.1520/MONO62013002815
Page Count:
33
  • Published:
    2014

Repair and regeneration of complex human musculoskeletal tissues such as long bones and limbs using biomaterials, cells, and/or growth factors is a great challenge for tissue engineers and orthopedic surgeons. Tissue engineering has long been considered an alternative to bone graft substitutes for bone regeneration. Recently regenerative engineering has emerged as the next stage in the evolution of tissue engineering. Regenerative engineering is an interdisciplinary field in which traditional tissue engineering converges with advanced materials science, stem cell science, and areas of developmental biology. In this chapter, we first briefiy introduce various commercially available bone grafting materials. Then we provide a state-of-the-art review on the tissue engineering approach to bone regeneration using biomaterials, cells, and growth factors. Finally, we emphasize the emergence of the field of regenerative engineering, aiming to overcome various challenges that researchers have faced in bone tissue engineering. The regenerative engineering approach to bone repair takes advantage of advances in materials science, stem cells, and developmental biology, and in our opinion represents the next era in engineering bone tissue.

Keywords:
bone, tissue engineering, regenerative engineering, convergence

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