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Performance of Protective Clothing
ASTM Selected Technical Papers
Performance of Protective Clothing
By
RL Barker
RL Barker
1
North Carolina State University School of Textiles
,
Raleigh, NC 27650
;
symposium chairman and editor
.
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GC Coletta
GC Coletta
2
Risk Control Services, Inc.
,
Tiburon, CA 94920
;
symposium chairman and editor
.
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ISBN-10:
0-8031-0461-8
ISBN:
978-0-8031-0461-7
No. of Pages:
653
DOI:
https://doi.org/10.1520/STP900-EB
Publisher:
ASTM International
Publication date:
1986
eBook Chapter

Bioassay for Testing Protective Glove Performance Against Skin Absorption of Organic Solvents

By
A Boman
A Boman
1
Research engineer, and professor
, respectively,
National Board of Occupational Safety and Health
, Research Department, Department of Occupational Dermatology,
S-171 84 Solna,
Sweden
.
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,
JE Wahlberg
JE Wahlberg
1
Research engineer, and professor
, respectively,
National Board of Occupational Safety and Health
, Research Department, Department of Occupational Dermatology,
S-171 84 Solna,
Sweden
.
2J. E. Wahlberg,
Karolinska Hospital
, Department of Occupational Dermatology,
Stockholm
Sweden
.
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Doi:
https://doi.org/10.1520/STP17316S
Page Count:
7
  • Published:
    1986

Solvents were administered into closed skin depots on guinea pigs, and the resulting blood concentrations were measured in samples repeatedly withdrawn through a catheter in the carotid artery. The exposure areas were protected with glove membranes of different kinds. Results from experiments with three solvents and various gloves are presented. The authors conclude that this animal model seems suitable for screening purposes and is capable of discerning between various commercial products.

Keywords:
protective gloves, percutaneous absorption, toluene, 1,1,1-trichloroethane, n-butanol, guinea pigs, blood concentrations, gas chromatography, protective clothing

References

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Occupational Skin Disease
,”
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72
,
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2.
Wahlberg
,
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 and
Boman
,
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, “
Comparative Percutaneous Toxicity of Ten Industrial Solvents in the Guinea Pig
,”
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5
,
1978
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,
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Edema-Inducing Effects of Solvents Following Topical Administration
,”
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,
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Wahlberg
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, “
Erythema-Inducing Effects of Solvents Following Epicutaneous Administration to Man—Studied by Laser Doppler Flowmetry
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, “
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,”
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,
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 and
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,
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, “
Penetration of Protective Gloves by Allergens and Irritants
,”
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, Vol.
59
,
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, pp. 230–234.
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Pegum
,
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 and
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, “
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,”
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, Vol.
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,
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,
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, “
Penetration of Protective Gloves by Epoxy Resin
,”
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, Vol.
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,
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Wall
,
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, “
Nickel Penetration Through Rubber Gloves
,”
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, Vol.
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,
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, pp. 461–463.
14.
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,
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,
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,
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, and
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,
G.
, “
A Method for the Study of the Effect of Barrier Creams and Protective Gloves on the Percutaneous Absorption of Solvents
,”
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, Vol.
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,
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, pp. 157–160.
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Jakobson
,
I.
,
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,
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,
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,
B.
, and
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,
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, “
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,”
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, Vol.
63
,
1982
, pp. 181–187.
16.
Andersen
,
K. E.
,
Maibach
,
H. I.
, and
Anjo
,
M. D.
, “
The Guinea Pig—An Animal Model for Human Skin Absorption of Hydrocortisone, Testosterone and Benzoic Acid?
”
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, Vol.
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,
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, pp. 447–453.
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,
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 and
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,
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, “
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” in
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 and
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, Eds.,
Hemisphere
,
Washington, DC
,
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.
18.
Nelson
,
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,
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,
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,
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,
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,
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,
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, and
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,
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, “
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.”
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, Vol.
42
,
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19.
Nolen
,
R. J.
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Evaluation of Protective Clothing Materials: Permeation, Degradation, Penetration and Particulate Analysis
,”
Radian Corp.
,
Austin, TX
,
1984
.
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