The stability of a bond cluster upon oscillated loads under physiological conditions is strongly regulated by the kinetics of association and dissociation of a single bond, which can play critical roles in cell–matrix adhesion, cell–cell adhesion, etc. Here, we obtain a simplified analysis for the bond association process of a constrained receptor to an oscillating ligand due to its diffusion-independence, which can facilitate the potential multiscale studies in the future. Based on the analysis, our results indicate that the mean passage time for bond association intriguingly saturates at high oscillating frequencies, and there can also surprisingly exist optimal bond elasticity for bond association. This work can bring important insights into understanding of the behaviors of bond cluster under cyclic loads at the level of a single bond.
Simplified Analysis for the Association of a Constrained Receptor to an Oscillating Ligand
Hangzhou 310027, China
Contributed by the Applied Mechanics Division of ASME for publication in the JOURNAL OF APPLIED MECHANICS. Manuscript received May 2, 2016; final manuscript received June 13, 2016; published online July 1, 2016. Editor: Yonggang Huang.
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Chen, X., and Chen, B. (July 1, 2016). "Simplified Analysis for the Association of a Constrained Receptor to an Oscillating Ligand." ASME. J. Appl. Mech. September 2016; 83(9): 091006. https://doi.org/10.1115/1.4033891
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