In this study, effects of cell culture on surface properties, and tribological performance were investigated. The wettability of Ni under dry and lubricated conditions, as well as cell-cultured specimens was evaluated. The tribological performance of these samples was compared using a pin-on-disk tribometer. Dry friction tests were conducted and compared with the bovine serum albumin (BSA) solution lubricated Ni and the cell culture media lubricated Ni. The lubrication behavior was discussed and new biofluid mechanisms were proposed.

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