Articular cartilage (AC) supports and distributes loads in synovial joints while maintaining a nearly frictionless surface. Successful replacement of large AC defects with an osteochondral graft requires an appropriate geometrical match with the defect region. 1 In AC, collagen (COL) provides tensile support to the tissue, and glycosaminoglycans (GAG) provide a fixed negative charge that produce swelling and contribute to the compressive properties of the tissue. 2 Previous studies ( Fig. 1) have shown that 4 days of bending can reshape immature AC, but without a change in the total COL and GAG concentrations. 3 We hypothesized that more localized COL and/or GAG remodeling occurs during AC reshaping and may support the shape change. The objective of this study was to determine the presence, magnitude and depth-dependence of COL and GAG remodeling that accompany the shape change of AC.
- Bioengineering Division
Matrix Remodeling Accompanies In Vitro Articular Cartilage Shaping
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Balcom, NT, Grisafe, DJ, Gutierrez-Franco, JD, Crawford, DJ, Raub, CB, Cory, E, Chen, AC, Hazelwood, SJ, Klisch, SM, & Sah, RL. "Matrix Remodeling Accompanies In Vitro Articular Cartilage Shaping." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT62A001. ASME. https://doi.org/10.1115/SBC2013-14106
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