Articular cartilage (AC) supports and distributes loads in synovial joints while maintaining a nearly frictionless surface. Successful replacement of large AC defects with an osteochondral graft requires an appropriate geometrical match with the defect region. 1 In AC, collagen (COL) provides tensile support to the tissue, and glycosaminoglycans (GAG) provide a fixed negative charge that produce swelling and contribute to the compressive properties of the tissue. 2 Previous studies ( Fig. 1) have shown that 4 days of bending can reshape immature AC, but without a change in the total COL and GAG concentrations. 3 We hypothesized that more localized COL and/or GAG remodeling occurs during AC reshaping and may support the shape change. The objective of this study was to determine the presence, magnitude and depth-dependence of COL and GAG remodeling that accompany the shape change of AC.

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