Chondrocytes occupy 2% to 5% of the volume of articular cartilage  and are responsible for maintenance of the tissue. In adult life, the healing and repair capacity of chondrocytes is very limited, and the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage. Excessive loading is known to be a cause of cell death.
- Bioengineering Division
Chondrocytes in Agarose: Cell Damage and the Pericellular Matrix
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van Turnhout, MC, de Vries, SAH, van Donkelaar, CC, & Oomens, CWJ. "Chondrocytes in Agarose: Cell Damage and the Pericellular Matrix." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT55A017. ASME. https://doi.org/10.1115/SBC2013-14458
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