Bioresorbable stents with limited functional lifetimes and with drug delivery capabilities are desired. Various methods have been investigated to induce porosity in bioresorbable polymeric stent fibers, thereby to permit increased drug reservoir capacity versus polymer-coated metal stents. We developed microporous surface layers on PLLA fibers to serve as the drug reservoir, but found that impurities, the use of chemicals, and multiple step procedures associated with our, and other published methods limited utility. Thus we investigated theoretically attractive CO 2 blowing methods, in which gas under pressure and temperature induces porosity. We report the results of initial studies of CO 2-induced porosity in PLLA stent fibers.
- Bioengineering Division
Influence of CO2 Blowing Agent on Porous Bioresorbable Stent Structure
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Barker, G, Welch, T, D’Souza, N, Nugent, A, & Eberhart, R. "Influence of CO2 Blowing Agent on Porous Bioresorbable Stent Structure." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT53A001. ASME. https://doi.org/10.1115/SBC2013-14073
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