This study investigates the use of longitudinal impedance (LI) as a means to quantify the severity of Type I Chiari Malformation (CMI). LI was analyzed in image-based models of the cervical spinal subarachnoid space of 22 CMI patients and 10 healthy volunteers. LI was then compared with the cerebellar tonsil herniation (CTH) measured by two neurosurgeons. Results showed that both LI and CTH differentiated CMI patients from healthy volunteers, but lacked the specificity to differentiate symptomatic and asymptomatic patients.
- Bioengineering Division
Relation of Cerebrospinal Fluid Flow Impedance and Cerebellar Herniation in Type I Chiari Malformation
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Shaffer, N, Martin, B, Rocque, B, Madura, C, Iskandar, B, Wieben, O, Dombrowski, S, Luciano, M, Oshinski, J, & Loth, F. "Relation of Cerebrospinal Fluid Flow Impedance and Cerebellar Herniation in Type I Chiari Malformation." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT46A006. ASME. https://doi.org/10.1115/SBC2013-14808
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