In the tissue engineered approach, cells seeded onto a scaffold produce with time a load bearing extra cellular matrix. At the same time the original scaffold degrades and the matrix takes over the mechanical function. The development of a collagen network in tissue engineered constructs strongly depends on the mechanical and chemical stimuli that are applied to the growing tissue . The morphology of the neo-formed tissue engineered collagenous networks is of fundamental importance for performance .
- Bioengineering Division
Modeling Collagen Synthesis and Degradation in Engineered Tissues Based on Fibrous Scaffolds
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Argento, G, Oomens, CWJ, & Baaijens, FPT. "Modeling Collagen Synthesis and Degradation in Engineered Tissues Based on Fibrous Scaffolds." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT45A003. ASME. https://doi.org/10.1115/SBC2013-14447
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