Percutaneous approaches to mitral valve (MV) repair have received a great deal of interest, as they avoid open-chest surgery and are often the only option for patients with significant co-morbidities . One technique currently in development is a combined radiofrequency (RF) ablation and cryo-anchoring catheter, and we recently demonstrated that reduction of MV leaflet surface area due to RF ablation is feasible in the proximity of cryo-anchoring . This reduction of enlarged, diseased MV leaflets is designed to improve leaflet coaptation and reduce mitral regurgitation. However, myocardial infarcts treated with RF ablation re-dilated in 20–30 days without the application of a retaining patch . Additionally, joint capsular tissues treated with RF ablation reduced in stiffness and ultimate strength over the first six weeks before regaining strength and stiffness . Re-dilation of MV tissues treated with combined RF ablation and cryo-anchoring would reverse the effects of the treatment strategy. Therefore, we hypothesized that excised porcine MV leaflets treated with combined RF ablation and cryo-anchoring would undergo little to no re-dilation over four weeks. Biaxial mechanical testing at 0 and 4 week time points and picrosirius red (PSR) staining was used to assess the degree of re-dilation and collagen morphological changes following 4 week bioreactor treatment of cyclic uniaxial tension.
- Bioengineering Division
Four Week Durability of Combined RF Ablation and Cryo-Anchoring Treatment for Mitral Valve Prolapse
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Boronyak, SM, & Merryman, WD. "Four Week Durability of Combined RF Ablation and Cryo-Anchoring Treatment for Mitral Valve Prolapse." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT30A002. ASME. https://doi.org/10.1115/SBC2013-14198
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