Within Regenerative Medicine, non-cell-based approaches such as biologically-derived materials have been commercially successful and represent an important proportion of medically-used biomaterials1. Several acellular matrices are commercially available, to be used as a reinforcement of soft tissue where weakness exists. The goal of this study was to determine whether out-of-package mechanical properties of an acellular tissue matrix was predictive of its in vivo interface strength and whether the in vivo interface strength was associated with a particular histological response. We chose to test three porcine dermis-derived acellular matrices and one bovine pericardium derived matrix.

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