Shear induced hemolysis (SIH) refers to the rupture of red blood cells in shear flows resulting in the release of hemoglobin into plasma. Hemolysis in turn triggers a chain of bio-chemical events involving all the components of blood leading to the formation of thrombosis (blood clots). While SIH is negligible in a healthy circulatory system, it is widespread in life saving blood contacting devices such as heart valves, ventricular assist devices, and blood pumps. Thus an accurate physical understanding of the process of hemolysis is critical towards developing better predictive models of SIH, particularly in the context of engineering future blood contacting devices that are significantly more blood cell friendly.
- Bioengineering Division
Phenomenology of Hemolysis in Turbulent Flows
- Views Icon Views
- Share Icon Share
- Search Site
Dasi, LP, Morshed, KN, & Forleo, M. "Phenomenology of Hemolysis in Turbulent Flows." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT05A020. ASME. https://doi.org/10.1115/SBC2013-14843
Download citation file: