Annulus dilation is one of the main causes of functional mitral regurgitation. Although the annulus dilation is usually accompanied by left ventricle dilation and dysfunction, the mechanical relation between them is not fully elucidated yet. In this paper, the assumption is made that the ventricular dysfunction increases the cyclic loading conditions on the mitral valve apparatus. This effect may cause fatigue and weaken the tissue. This hypothesis is investigated in vitro by applying increased cyclic loadings to the tissue and evaluating the tissue stiffness during the cycles. The results of this study show that the tissue loses its strength after cyclic fatigue loadings.
- Bioengineering Division
Investigation of the Fatigue Properties of Mitral Valve Leaflets
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Shahmansouri, N, Javid, F, Pasini, D, Angeles, J, Amabili, M, & Mongrain, R. "Investigation of the Fatigue Properties of Mitral Valve Leaflets." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A027. ASME. https://doi.org/10.1115/SBC2013-14758
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