Despite half a century of use, mechanical heart valves still require further research to reduce the non-physiologic nature of the flow field, which is the source of potential medical complications, of which the most serious complication is thrombus formation . In the systolic phase of the flow, excessive fluid stresses are generated by the non-physiologic flow patterns [2, 3]. In the closed valve position, a large pressure gradient is imposed across the device which leads to the generation of strong and damaging small-scale leakage flows that entrain platelets such that they are exposed to elevated stresses for excessive time durations [4–6].
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Small Scale Flow Structure Evolution During Mechanical Heart Valve Closure
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Mousel, J, Udaykumar, HS, & Chandran, KB. "Small Scale Flow Structure Evolution During Mechanical Heart Valve Closure." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A019. ASME. https://doi.org/10.1115/SBC2013-14603
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