Coronary artery disease and peripheral artery disease remain a significant source of mortality and vascular morbidity in the United States; both affecting over 14 million Americans. Although a number of both open and endovascular procedures are available for treating occlusive lesions, post-procedure intimal hyperplasia (IH) and pathological wall adaptation in treated arteries cause further need for treatment. As on average 50% of patients receiving these treatments must receive further vascular intervention to prevent the continued expansion of IH into the vessel lumen, there is a need to improve our understanding of the underlying causes of IH formation.
- Bioengineering Division
Reduction in Mechanical Wall Strain Precedes Intimal Hyperplasia Formation in a Murine Model of Arterial Occlusive Disease
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Favreau, JT, Liu, C, Yu, P, Mauro, C, Tao, M, Ozaki, CK, & Gaudette, GR. "Reduction in Mechanical Wall Strain Precedes Intimal Hyperplasia Formation in a Murine Model of Arterial Occlusive Disease." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A016. ASME. https://doi.org/10.1115/SBC2013-14475
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