Splines are the standard tools in computer aided design for geometric representations and have been recently integrated into the finite element analysis of structures and fluids . As the biomedical engineering is making progress, there is a need for an integrated tool for expanding the geometrical representation to include the microstructural details specific to soft tissue, e.g. fiber alignment, orientation, crimp and stiffness. In this work, a spline-based method is presented for aortic valves which facilitates mapping of the fiber structure from any aortic valve specimen to any other aortic valve geometry through a common parameter space. This techniques also has the ability to calculate mean tissue microstructure of representative population. Also strain and pre-strain from in-vivo state to the in-vitro state, where all the mechanical tests are done, are calculated for forward and inverse modeling of aortic valves.
- Bioengineering Division
Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves
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Aggarwal, A, Aguilar, VS, Lee, CH, Ferrari, G, Gorman, JH, Gorman, RC, & Sacks, MS. "Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A006. ASME. https://doi.org/10.1115/SBC2013-14265
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