Tissue engineering represents a promising technique to overcome the limitations of the current valve prostheses, since it allows for synthesizing living, autologous valves that have the potential to grow and remodel in response to changing demands. However, one particular problem with tissue-engineered heart valves (TEHVs) is retraction of the valve leaflets (Fig. 1), which results in valvular insufficiency [1, 2]. As long-term regurgitation will lead to ventricular failure, this is a critical problem that needs to be solved before TEHVs can be used in clinical practice.
- Bioengineering Division
Effects of Valve Geometry and Tissue Anisotropy on the Radial Stretch and Coaptation Area of Tissue-Engineered Heart Valves
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Loerakker, S, Argento, G, Oomens, CWJ, & Baaijens, FPT. "Effects of Valve Geometry and Tissue Anisotropy on the Radial Stretch and Coaptation Area of Tissue-Engineered Heart Valves." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A004. ASME. https://doi.org/10.1115/SBC2013-14234
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