Osteoarthritis (OA), commonly known as ‘wear and tear’ in human joints, affects over 27 million people in the United States . There is currently no encompassing solution for the regeneration of damaged articular cartilage. One potential solution involves the close emulation of the native structure of articular cartilage, with special consideration given to maintaining the distinct organized zonal ultrastructure, characterized by both random and highly aligned zones of collagen fibrils, in order to preserve mechanical and cell signaling properties of the extracellular matrix . Techniques such as electrospinning achieve high degrees of alignment, but do so at the cost of denaturing the collagen molecule  that may lead to inferior cell recognition and mechanical strength.
- Bioengineering Division
Temperature Control During Fibrillogenesis Allows for Improved Magnetic Alignment of Collagen
Shannon, G, Novak, T, Voytik-Harbin, SL, & Neu, CP. "Temperature Control During Fibrillogenesis Allows for Improved Magnetic Alignment of Collagen." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT02A004. ASME. https://doi.org/10.1115/SBC2013-14314
Download citation file: