The Fontan operation is the final stage of palliative surgery for children born with single ventricle heart defects. The most common configuration is called total cavopulmonary connection (TCPC), wherein the inferior vena cava and superior vena cava are anastomosed directly to the pulmonary arteries; therefore the pulmonary circulation is driven by venous pressure only. The Fontan procedure, although successful in the early postoperative period, with time can decrease in efficiency or even fail within several years after the operation. The reasons of different clinical outcomes for some of the Fontan patients are not clear enough, even though it is commonly accepted that certain factors such as low pulmonary vascular resistance and proper shape and size of the TCPC construction are crucial for the succesful long term outcomes. Accordingly, one of the major problems is the increase in pulmonary vascular resistance due to altered hemodynamics after the surgery, causing venous hypertension and respiratory-dependent pulmonary regurgitation [1]. The main pulmonary arteries may also see increased resistance due to congenital malformations, surgical scarring, or deliberate surgical banding. Thus, the consequence of the increased pulmonary vascular resistance at both proximal and distal locations with respect to the TCPC junction, and its effect on the systemic pressures and flow rates, is the main objective of this study.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
In Vitro Study of Pulmonary Vascular Resistance in Fontan Circulation With Respiration Effects
Marija Vukicevic,
Marija Vukicevic
Clemson University, Clemson, SC
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Timothy A. Conover,
Timothy A. Conover
Clemson University, Clemson, SC
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Tain-Yen Hsia,
Tain-Yen Hsia
Medical University of South Carolina, Charleston, SC
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Richard S. Figliola
Richard S. Figliola
Clemson University, Clemson, SC
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Marija Vukicevic
Clemson University, Clemson, SC
Timothy A. Conover
Clemson University, Clemson, SC
Jian Zhou
Clemson University, Clemson, SC
Tain-Yen Hsia
Medical University of South Carolina, Charleston, SC
Richard S. Figliola
Clemson University, Clemson, SC
Paper No:
SBC2012-80888, pp. 985-986; 2 pages
Published Online:
July 19, 2013
Citation
Vukicevic, M, Conover, TA, Zhou, J, Hsia, T, & Figliola, RS. "In Vitro Study of Pulmonary Vascular Resistance in Fontan Circulation With Respiration Effects." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 985-986. ASME. https://doi.org/10.1115/SBC2012-80888
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