Although bone has the intrinsic ability to “self-heal”, there are circumstances in which its regenerative capacity is limited or compromised, such as in critical bone defects. In these cases, the lack of osteogenic proteins at the wound site can prevent healing and external stimuli may be necessary to encourage bone growth [1]. Exogenous delivery of proteins and growth factors directly to the wound has been successful in bone regeneration, but is limited by the instability of the proteins and short half-lives. As a result, administration of multiple large doses of protein is necessary to retain a beneficial protein level. Due to these disadvantages, additional methods have been investigated to supply essential proteins to the bone defect [2].
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Thermal Stress Conditioning to Induce Osteogenic Protein Expression for Bone Regeneration Available to Purchase
Alana C. Sampson,
Alana C. Sampson
Virginia Tech - Wake Forest University, Blacksburg, VA
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Eunna Chung,
Eunna Chung
Virginia Tech - Wake Forest University, Blacksburg, VA
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Marissa Nichole Rylander
Marissa Nichole Rylander
Virginia Tech - Wake Forest University, Blacksburg, VA
Search for other works by this author on:
Alana C. Sampson
Virginia Tech - Wake Forest University, Blacksburg, VA
Eunna Chung
Virginia Tech - Wake Forest University, Blacksburg, VA
Marissa Nichole Rylander
Virginia Tech - Wake Forest University, Blacksburg, VA
Paper No:
SBC2012-80940, pp. 953-954; 2 pages
Published Online:
July 19, 2013
Citation
Sampson, AC, Chung, E, & Rylander, MN. "Thermal Stress Conditioning to Induce Osteogenic Protein Expression for Bone Regeneration." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 953-954. ASME. https://doi.org/10.1115/SBC2012-80940
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