Irreversible electroporation (IRE) is a new minimally invasive non-thermal focal ablation technique that has been used for the treatment of spontaneous tumors in canine and human patients [1–4]. The procedure involves placing electrodes into or around a tumor and delivering a series of low energy electric pulses to kill tumor tissue with sub-millimeter resolution. The pulses generate an electric field that alters the resting transmembrane potential (TMP) of the cells . Depending on the magnitude of the induced TMP, the electric pulses can have no effect, transiently increase membrane permeability, or cause cell death .
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A Comparison Between the Pulsed and Duty Cycle Approaches Used to Capture the Thermal Response of Tissue During Electroporation-Based Therapies
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Garcia, PA, Pearce, JA, & Davalos, RV. "A Comparison Between the Pulsed and Duty Cycle Approaches Used to Capture the Thermal Response of Tissue During Electroporation-Based Therapies." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 945-946. ASME. https://doi.org/10.1115/SBC2012-80574
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