Mathematical description of biological processes, including cell growth, cell differentiation, cell response to stress, and cell damage and death, could be beneficial to the characterization, quantitative evaluation, design, and optimization of the relevant processes. Phenomenological modeling based on experiments would be a promising method for the abovementioned description, although modeling should ideally be based on the outcome of system biological studies. Mathematical models have been developed for characterizing cell damage and death by hyperthermic stress and hypertonic electrolyte solution stress in relation to the medical application of bioheat transfer [1,2].

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