As platelets are transported they are continuously stretched, compressed and sheared by local gradients in the flow. Exposure to elevated gradients can cause platelets to actively react with conformational, chemical and enzymatic responses, i.e. becoming activated. Once switched to the activated state, platelets perform multifaceted roles to orchestrate clotting. Mechanically-induced platelet activation under pathological conditions has been studied since the late 1970s. This work builds on [1], which introduced a trajectory-based level of activation parameter for platelets, and [2] describing coherent structures in cardiovascular flow. We introduce a new direction-independent Lagrangian measure. This measure is introduced as an activation potential in two senses. First, it provides a measure of mechanical strain, which has been shown to have the potential to activate platelets. Second, it is plotted at the initial location of the platelets. This latter condition is subtle, but it enables us to uncover an interesting observation that locations of highest activation potential tend to occur along structures that have important implications to the transport topology.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Potential Pathways for Platelet Activation
Shawn C. Shadden,
Shawn C. Shadden
Illinois Institute of Technology, Chicago, IL
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Sahar Hendabadi
Sahar Hendabadi
Illinois Institute of Technology, Chicago, IL
Search for other works by this author on:
Shawn C. Shadden
Illinois Institute of Technology, Chicago, IL
Sahar Hendabadi
Illinois Institute of Technology, Chicago, IL
Paper No:
SBC2012-80474, pp. 889-890; 2 pages
Published Online:
July 19, 2013
Citation
Shadden, SC, & Hendabadi, S. "Potential Pathways for Platelet Activation." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 889-890. ASME. https://doi.org/10.1115/SBC2012-80474
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