Blood recirculating devices, which include ventricular assist devices and prosthetic heart valves, are necessary for some patients suffering from end-stage heart failure and valvular diseases. However, disturbed flow patterns in these devices cause shear-induced platelet activation and aggregation. Thromboembolic complications resulting from this platelet behavior necessitates lifelong anticoagulant therapy for patients implanted with such devices. In addition, blood recirculating device manufacturers mostly test and optimize their products for hemolysis, which occurs at shear stresses ten-fold higher than required for platelet activation. The relative paucity of optimization for flow-induced thrombogenicity is further exacerbated by the fact that there are few predictive shear-induced platelet activation models.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Evaluation of Platelet Activation Models With Dynamic Shear Stress In Vitro Experiments Available to Purchase
Jawaad Sheriff,
Jawaad Sheriff
Stony Brook University, Stony Brook, NY
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Michalis Xenos,
Michalis Xenos
Stony Brook University, Stony Brook, NY
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João S. Soares,
João S. Soares
Stony Brook University, Stony Brook, NY
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Jolyon Jesty,
Jolyon Jesty
Stony Brook University, Stony Brook, NY
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Danny Bluestein
Danny Bluestein
Stony Brook University, Stony Brook, NY
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Jawaad Sheriff
Stony Brook University, Stony Brook, NY
Michalis Xenos
Stony Brook University, Stony Brook, NY
João S. Soares
Stony Brook University, Stony Brook, NY
Jolyon Jesty
Stony Brook University, Stony Brook, NY
Danny Bluestein
Stony Brook University, Stony Brook, NY
Paper No:
SBC2012-80134, pp. 883-884; 2 pages
Published Online:
July 19, 2013
Citation
Sheriff, J, Xenos, M, Soares, JS, Jesty, J, & Bluestein, D. "Evaluation of Platelet Activation Models With Dynamic Shear Stress In Vitro Experiments." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 883-884. ASME. https://doi.org/10.1115/SBC2012-80134
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