It is known that mechanical factors play a key role in bone formation and regulation of tissue regeneration during skeletal healing. However, the underlying mechanisms are not fully understood. Mechanical loads, such as cyclic compression, torsion and bending are key factors driving the differentiation of mesenchymal stem cells (MSCs). On the other hand, excessive mechanical loading may disrupt the process of healing and lead to non-unions and cell apoptosis. Therefore, effective positive mechanical factors are bounded by a range and frequency. A number of mechanoregulation algorithms have been developed by comparing tissue differentiation patterns under different loading regimes [1, 2, 3, 4]. The aim of this study was to predict the development of differentiated tissues in a closed fracture model treated with a stem cell seeded soft collagenous scaffold under load regimes of axial compression, bending and torsion. The long term goal is to improve our understanding of fracture healing in non-union fractures and develop stem cell based tissue engineering treatments.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Simulation of Tissue Differentiation During Fracture Healing Within a Collagenous Scaffold Implanted in a Murine Tibia With an Oblique Fracture Available to Purchase
Saghar Nasr,
Saghar Nasr
University of Calgary, Calgary, AB, Canada
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Neil A. Duncan
Neil A. Duncan
University of Calgary, Calgary, AB, Canada
Search for other works by this author on:
Saghar Nasr
University of Calgary, Calgary, AB, Canada
Neil A. Duncan
University of Calgary, Calgary, AB, Canada
Paper No:
SBC2012-80852, pp. 875-876; 2 pages
Published Online:
July 19, 2013
Citation
Nasr, S, & Duncan, NA. "Simulation of Tissue Differentiation During Fracture Healing Within a Collagenous Scaffold Implanted in a Murine Tibia With an Oblique Fracture." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 875-876. ASME. https://doi.org/10.1115/SBC2012-80852
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