Wall shear stress and statin drugs have both been shown to influence endothelial cell function. We investigated the effect of statins on the morphology and F-actin cytoskeleton arrangement of endothelial cells with and without wall shear stress. Under static conditions, statins caused cells to become rounded and disorganized the F-actin cytoskeleton. Wall shear stress abrogated the morphological effects, but did not reverse the cytoskeleton disorganization.
Volume Subject Area:Poster Session I: Student Paper Competition (MS Level) - Fluids, Cells Mechanics, Tissue Engineering
Topics:Endothelial cells, Shear stress, Drugs
This content is only available via PDF.
Copyright © 2012 by ASME