Fractional flow reserve (FFR: ratio of distal to proximal pressure of a stenotic section) is used to evaluate hemodynamic significance of epicardial stenosis. However, FFR and coronary flow reserve (CFR: ratio of hyperemic blood velocity to that of resting condition) are used in conjunction to evaluate combination of both epicardial and microvascular disease. It has been proposed that optimization of cutoff values for diagnostic parameters in determining stenosis severity depends on coupling functional (pressure and velocity) and anatomical data (% area stenosis). We hypothesize that, pressure drop coefficient (CDP: the ratio of trans-stenotic pressure drop to distal dynamic pressure) which has the functional information of pressure and velocity in its formulation correlates significantly with FFR and CFR, and lesion flow coefficient (LFC: ratio of % area stenoses to CDP at throat region) which combines both functional and anatomical (% area stenoses) information in its formulation correlates significantly with FFR, CFR and % area stenosis. We retrospectively analyzed the hemodynamic information from Meuwissen et al [3] to test this hypothesis. It was observed that, CDP, a functional index based on pressure drop and velocity, correlated linearly and significantly with FFR and CFR. And, LFC (combined functional and anatomic parameter) also correlated significantly with FFR, CFR (both hemodynamic endpoints) and % area stenosis (anatomic endpoint).
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Functional and Anatomical Diagnosis of Coronary Artery Stenoses: A Retrospective Study in Humans
Kranthi K. Kolli,
Kranthi K. Kolli
University of Cincinnati, Cincinnati, OH
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Mohamed Effat,
Mohamed Effat
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
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Imran Arif,
Imran Arif
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
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Tarek Helmy,
Tarek Helmy
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
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Massoud Leesar,
Massoud Leesar
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
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Lloyd H. Back,
Lloyd H. Back
California Institute of Technology, Pasadena, CA
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Srikara V. Peelukhana,
Srikara V. Peelukhana
University of Cincinnati, Cincinnati, OH
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Rupak K. Banerjee
Rupak K. Banerjee
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
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Kranthi K. Kolli
University of Cincinnati, Cincinnati, OH
Mohamed Effat
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
Imran Arif
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
Tarek Helmy
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
Massoud Leesar
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
Lloyd H. Back
California Institute of Technology, Pasadena, CA
Srikara V. Peelukhana
University of Cincinnati, Cincinnati, OH
Rupak K. Banerjee
University of Cincinnati, Cincinnati, OH
Cincinnati Veteran Affairs Medical Center, Cincinnati, OH
Paper No:
SBC2012-80552, pp. 77-78; 2 pages
Published Online:
July 19, 2013
Citation
Kolli, KK, Effat, M, Arif, I, Helmy, T, Leesar, M, Back, LH, Peelukhana, SV, & Banerjee, RK. "Functional and Anatomical Diagnosis of Coronary Artery Stenoses: A Retrospective Study in Humans." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 77-78. ASME. https://doi.org/10.1115/SBC2012-80552
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