Many native and bioengineered soft tissues are composed of two or more types of biopolymer networks that mechanically define and support the material [1]. Modeling the response of multi-network soft tissues to mechanical loading can be difficult due to the heterogeneous nature of these materials and the large strains (>1) involved. As tissues deform, the different biopolymer networks interact with one another and determine the overall stress-strain outcome for the tissue. Capturing this interaction could help improve the accuracy of a computer model to simulate the microscale behavior of soft tissues under load. We have developed a two-network model to reflect interactions between collagen and fibrin biopolymer networks loaded in uniaxial extension. The model can help improve our understanding of native and engineered tissue mechanics.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
A Microscale Collagen-Fibrin Interacting Network Model With Comparison to Experimental Results Available to Purchase
Jeffrey D. Hyypio,
Jeffrey D. Hyypio
University of Minnesota, Minneapolis, MN
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Mohammad F. Hadi,
Mohammad F. Hadi
University of Minnesota, Minneapolis, MN
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Victor K. Lai,
Victor K. Lai
University of Minnesota, Minneapolis, MN
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Victor H. Barocas
Victor H. Barocas
University of Minnesota, Minneapolis, MN
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Jeffrey D. Hyypio
University of Minnesota, Minneapolis, MN
Mohammad F. Hadi
University of Minnesota, Minneapolis, MN
Victor K. Lai
University of Minnesota, Minneapolis, MN
Victor H. Barocas
University of Minnesota, Minneapolis, MN
Paper No:
SBC2012-80656, pp. 763-764; 2 pages
Published Online:
July 19, 2013
Citation
Hyypio, JD, Hadi, MF, Lai, VK, & Barocas, VH. "A Microscale Collagen-Fibrin Interacting Network Model With Comparison to Experimental Results." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 763-764. ASME. https://doi.org/10.1115/SBC2012-80656
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