Traction force generated at focal adhesions (FAs) of cells plays an essential role in regulating various cellular functions. The force can be measured by plating cells on a flexible substrate to observe local displacement of the substrate caused by the forces (1–100 nN) . Approaches employing this method include using microfabricated arrays of poly(dimethylsiloxane) (PDMS) micropillars that bend by cellular traction forces . If you could apply forces to individual FAs independently by actively moving micropillars, it should become a powerful tool to delineate the cellular mechanotransduction mechanisms.
- Bioengineering Division
Development of a Novel Magnetic-Driven Micropillar Substrate for Mechanical Stimulation at Individual Focal Adhesions of Cells
Nagayama, K, Hamada, Y, Inoue, T, & Matsumoto, T. "Development of a Novel Magnetic-Driven Micropillar Substrate for Mechanical Stimulation at Individual Focal Adhesions of Cells." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 683-684. ASME. https://doi.org/10.1115/SBC2012-80213
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