The cervix plays a critical role during pregnancy, acting as a mechanical barrier to keep the fetus inside the uterus until term. In a normal pregnancy, it is hypothesized that the cervix gradually softens until uterine contractions occur. At this point, the cervix dramatically ripens and dilates for delivery. Similar to other collagenous tissues, the extracellular matrix (ECM) is the load-bearing component of cervical tissue. It is composed mainly of a cross-linked network of fibril forming collagen, types I and III, embedded in a viscous proteoglycan ground substance. Studies conducted on animal models suggest that during normal maturation, a shift in ECM components facilitate cervical softening. However, quantitative cervical softness measurements (i.e. material properties) of these previous studies are ill-defined, limiting the comparative ability of the outcome values. Therefore, our goal is to quantify sensitive and specific time-dependent material properties utilizing mouse models of normal and abnormal pregnancy. Our aim is to discern the role of ECM maintenance in cervical softening.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Anthrax Toxin Receptor 2 Knock-Out and Wild Type Mouse Cervix Exhibit Time-Dependent Mechanical Properties
Kyoko Yoshida,
Kyoko Yoshida
Columbia University, New York, NY
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Claire Reeves,
Claire Reeves
Columbia University, New York, NY
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Jan Kitajewski,
Jan Kitajewski
Columbia University, New York, NY
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Ronald Wapner,
Ronald Wapner
Columbia University, New York, NY
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Michael Fernandez,
Michael Fernandez
Columbia University, New York, NY
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Kristin Myers
Kristin Myers
Columbia University, New York, NY
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Kyoko Yoshida
Columbia University, New York, NY
Claire Reeves
Columbia University, New York, NY
Jan Kitajewski
Columbia University, New York, NY
Ronald Wapner
Columbia University, New York, NY
Joy Vink
Columbia University, New York, NY
Michael Fernandez
Columbia University, New York, NY
Kristin Myers
Columbia University, New York, NY
Paper No:
SBC2012-80732, pp. 519-520; 2 pages
Published Online:
July 19, 2013
Citation
Yoshida, K, Reeves, C, Kitajewski, J, Wapner, R, Vink, J, Fernandez, M, & Myers, K. "Anthrax Toxin Receptor 2 Knock-Out and Wild Type Mouse Cervix Exhibit Time-Dependent Mechanical Properties." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 519-520. ASME. https://doi.org/10.1115/SBC2012-80732
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