Bone is an adaptive material, which is particularly responsive to mechanical loading and can adapt its mass and structure to meet the mechanical demands experienced throughout life. The osteocyte, due to its ubiquitous presence throughout bone, is believed to act as the main sensor of mechanical stimulus in bone, recruiting other cells to control bone growth and resorption in response to changes in physiological demands. However the precise mechanical stimuli that osteocytes experience in vivo, and what type of stimulus instigates an adaptive response, are not fully understood.
- Bioengineering Division
Loading-Induced Interstitial Fluid Flow in Bone Mechanobiology: An FSI Approach to the Osteocyte Environment
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Verbruggen, SW, Vaughan, TJ, & McNamara, LM. "Loading-Induced Interstitial Fluid Flow in Bone Mechanobiology: An FSI Approach to the Osteocyte Environment." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 517-518. ASME. https://doi.org/10.1115/SBC2012-80687
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