Investigating Electromagnetic Field, Nanoparticle Design, and Treatment Volume for Magnetic Nanoparticle Thermal Therapy

Magnetic nanoparticle (MNP) based thermal therapies are currently approved in Europe and poised for clinical translation in the US. The main benefits include the ability to focally and repeatedly treat tissues, including cancers, with a minimally-invasive platform. Nevertheless, a more complete understanding and control of MNP heating is necessary to effectively translate the approach to treat different sizes and geometries of cancer (See Figure 1). The present work discusses contrasts in heating between superparamagnetic and ferromagnetic nanoparticles (sMNP and fMNP), electromagnetic field-dependant MNP response, scaling of MNP volumetric heating, and the ability of theory to predict this behavior.