Inflammation has been recognized as a major integral component for most of the acute and chronic diseases. Inflammation can be initiated within the body as an innate process or by external factors such as infections and trauma. Inflammation is a complex and dynamic process, and involves nonlinearity and stochasticity. Without the inflammation, the harmful stimuli cannot be removed and the healing process cannot occur. However, an over-expression or under-expression of inflammatory responses can lead to severe consequences, such as Multiple Organ Dysfunction Syndrome (MODS), which is characterized by sequential organ failure. Acute lung injury (ALI) is typically one of the first manifestation of MODS. It can be triggered by external stimuli such as pathogens or from inflammatory mediators produced from various other processes ranging from other damaged organs or to blood transfusions to even the biomechanical forces of mechanical ventilation itself.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Airway Inflammation Induced by Mechanical Ventilation Through Multiscale Modeling
Ramana M. Pidaparti,
Ramana M. Pidaparti
Virginia Commonwealth University, Richmond, VA
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Kevin R. Ward
Kevin R. Ward
Virginia Commonwealth University, Richmond, VA
Search for other works by this author on:
Ramana M. Pidaparti
Virginia Commonwealth University, Richmond, VA
Kevin R. Ward
Virginia Commonwealth University, Richmond, VA
Paper No:
SBC2012-80174, pp. 395-396; 2 pages
Published Online:
July 19, 2013
Citation
Pidaparti, RM, & Ward, KR. "Airway Inflammation Induced by Mechanical Ventilation Through Multiscale Modeling." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 395-396. ASME. https://doi.org/10.1115/SBC2012-80174
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