Exogenous Temporal Assessment of Lysyl Oxidase on Engineered Articular Cartilage as a Method for Promoting Collagen Crosslinking Available to Purchase

The poor ability of articular cartilage (AC) to repair following disease and/or injury makes the tissue a key target for cell-based regenerative strategies. Progress made in the development of tissue engineered AC, using a 3-dimensional, scaffoldless, self-assembly method, has yielded neotissues with compressive properties on par with native tissue [1]. However, the tensile properties of these engineered tissues remain to be improved. This is particularly important because, while the tissue functions mainly in compression, the tensile strains within the joint nonetheless present a mechanically challenging environment.