Sustained mechanical loading of soft tissues covering bony prominences may lead to degeneration of skeletal muscle tissue. This can result in a condition termed deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, and progresses towards the skin. Previously, we have provided evidence that in a controlled animal model, deformation is the main trigger for damage within a 2 h loading period [1,2]. Recently, we also showed that ischemia and reperfusion may contribute to the damage process during prolonged loading . In the present study, we investigated the relative effects of deformation, ischemia, and reperfusion on the temporal and spatial damage process of skeletal muscle tissue during a 6 h period using magnetic resonance imaging (MRI) techniques.
- Bioengineering Division
The Relative Contributions of Muscle Deformation and Ischemia to Pressure Ulcer Development
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Loerakker, S, Strijkers, GJ, Nicolay, K, Baaijens, FPT, Bader, DL, & Oomens, CWJ. "The Relative Contributions of Muscle Deformation and Ischemia to Pressure Ulcer Development." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 375-376. ASME. https://doi.org/10.1115/SBC2012-80239
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